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A new platform for combinatorial drug discovery to combat antibiotic resistance

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Published on Jun 15, 2018

The Blainey lab at the Broad Institute is helping address the challenge of antibiotic resistance by helping identify drugs and compounds that can help antibiotics enter bacteria more easily or boost their activity.

Here, members of the Blainey lab describe a bench-top platform that uses uses optical color-coding and droplet microfluidics to test thousands of drug-antibiotic combinations at a time.

Paper cited: Kulesa A, Kehe J, et al. Combinatorial drug discovery in nanoliter droplets. PNAS. Published online June 13, 2018. DOI: 10.1073/pnas.1802233115

Copyright Broad Institute, 2018. All rights reserved.

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