 Antibiotic resistance genes, ARJs, have accelerated microbial threats to human health. Here, Zhong et al. analyze 4,572 metagenomic samples to illustrate the global patterns of ARG distribution in diverse habitats. They quantitatively evaluate the health risk to humans of 2,561 ARJs by integrating human accessibility, mobility, pathogenicity, and clinical availability. With the machine learning, they map the antibiotic-resistant threats in global marine habitats. This article was authored by Sinyin Zhong, Qi Zhong, Ting Zhong Wang, and others.