 NiF2 is a transcription factor that plays a key role in protecting cells from oxidative stress. It has been shown to activate the expression of genes involved in detoxification and antioxidant defense mechanisms. Recent studies have also revealed that NiF2 can affect cellular energy metabolism. This study demonstrates that NiF2 deficiency causes mitochondrial dysfunction, leading to decreased ATP production and impaired respiration. The authors found that NiF2 deficient cells rely on glycolysis to produce ATP, which is then used to maintain the mitochondrial membrane potential. They also showed that NiF2 deficient cells have reduced activity of the respiratory chain complexes, suggesting that NiF2 plays a critical role in maintaining proper mitochondrial function. This article was authored by Kira M. Holmstrom, Liam Baird, Ying Zhong, and others. We are article.tv, links in the description below.