 This study analyzed social media data from Twitter to identify community interactions related to vaccines and key influences, influences before and after the COVID-19 pandemic in Turkey. The results showed that media figures and authors with anti-vaccine views were the most influential users in the pre-COVID-19 network, while the Turkish Minister of Health was the most influential figure in the post-COVID-19 network. The vaccine network grew rapidly after COVID-19, and physicians and authors who had opinions about mandatory vaccinations received a great deal of reaction. One-way communication between influencers and other users in the network was determined. The study highlights the effectiveness and usefulness of large social media data for understanding public opinion on public health and vaccination in Turkey, and suggests that social network analysis could help reduce the infodemic before administering the vaccine and act more proactively in this regard. This article was offered by Nihal Durmas and Indian Hen German. We are article.tv, links in the description below.