 Mycobacterium tuberculosis encodes three different types of translation polymerases, which are responsible for repairing damaged DNA. These polymerases are known as DIN B1, DIN B2, and DNAE2. DIN B2 has been shown to be particularly active in causing mutations in mycobacterial cells, and it is capable of inducing both substitution and frame shift mutations. Furthermore, this polymerase is able to use manganese to increase its mutatonicity, suggesting that it may play a key role in the development of antibiotic resistance in M. This article was authored by Pierre Dupuis, Shreya Ghosh, Alison Faye, and others.