 Hello everyone and welcome to the next edition of the BIOXCEL webinar series. My name is Rosen Apostolov and I will be today's host. These webinar series are brought to you by BIOXCEL, the leading European Centre of Excellence for Computational Biomolecular Research. In this series we feature notable scientists and their work in the domain of biomolecular sciences. We feature developers of popular software applications, new release tools which we believe might be of interest for the community, as well as educational webinars for those of you who are new to the field. And last but not least, we present sometimes some of the major achievements of the work done in our centre. We hope that these series are of interest and bring value to your work and if you'd like us to invite specific speakers or if you'd like us to feature given topics, please get in touch with us and we'll be happy to organise them. For more information and context, please visit www.bioxcel.io. Before we begin, I have to tell you that this webinar is being recorded and after it's finished we will put a recording on the YouTube channel of BIOXCEL and also on the website, which is very useful for those of you who couldn't make it to the live event today and you can also share it with your friends and colleagues. At the end of the presentation today we will have a question and answer session. For that, at any time during the presentation today, please feel free to use the questions tab on your webinar control panel. At the end of the talk, I will give you the opportunity to ask your question directly. If there is problem with the audio, I will then read the question on your behalf. If you have some other questions or you're watching a recording of this session, please visit www.bioxcel.io and post your questions there in the relevant discussion forum. With that, I'd like to present today's presenter. This is Karsten Kussner from Max Planck Institute for Biophysical Chemistry. Karsten studied physics at the University of Göttingen and in his PhD he focused on simulations of the Earth's magnetic field, which brought him in contact with high-performance and parallel computing. Then he studied MPI for solar system research and eventually moved to computational biophysics. Since 2004, he's been working at the Max Planck Institute for Biophysical Chemistry in the group of Helmut Kurmüller. His interests are in the method of development, high-performance computing and domestic biomolecular simulations. Those of you who follow the development of Gromovs are probably familiar with a lot of Karsten's work. You can find him on Twitter at Kussner Karsten and also at the Combine Office tag. You can visit his web page as well. With that, I'd like to welcome Karsten to who there was about his talk today. Hello everybody, I hope you can hear me well. It's nice to have so many people interested in what is the optimal hardware for Gromax molecular-dynamic simulations. I'm going to start right with our motivation. Many other MD groups worldwide probably want to find optimal hardware to run Gromax simulations on them. Many groups have a fixed budget to buy small to medium-owned clusters. Of course, you want to make optimal use of that budget. In our case and probably in many other cases as well, we run mostly Gromax software on our cluster. We can really tailor the nodes for Gromax. Our strategy is to maximize cost efficiency by specialization. What is probably also quite often the case, our key was always full. We really optimize the hardware for throughput and for single-node performance. If people want to do strong scaling or have the smallest time-to-solution for a single simulation or so, we ask them to go to the HPC centers, which are very well equipped for that type of usage. The overall question is stated here. Given a fixed budget, how can we actually produce as much MD trajectory as possible from that? I will give a quick outline. This is an ongoing investigation. A few years ago, we did a similar paper about what is the optimal hardware for Gromax 4.6. In this talk, we are going to quickly recap what were all conclusions back then, a few years ago. We are going to look at both hardware and software development during the last four or five years and what the impact is on the hardware choices that one would make today. We have also written up recently our findings and updates to the original paper where you might want to look up the details if you are interested. Our approach is actually quite simple. We assemble a bunch of CPU types and GPU models and on all of the different combinations of that, we benchmark Gromax. We look at nodes with just CPUs. Here are a few examples. We look at AMD CPUs, for example Ryzen and Epic. We look at Intel CPUs like Core i7 or Xeons, between 4 and 20 cores. We also plug in GPUs up to 4 in a node. We both look at consumer GPUs, mostly at these here in the green box and also at professional GPUs like Tesla v100. For that, we determine the prices and the performances and the performance to price ratio. I should say that we are not aiming at a comprehensive evaluation of all currently available hardware because that's far too much. We just aim to uncover hardware with a good performance to price ratio and if we already know that certain components will be very expensive and not going to lead to a good performance to price ratio, then we're not really assembling nodes from that. Also, we are not looking at strong scaling. These are the two benchmark MD systems that we use for our investigation. There's one very typical MD system. It's an 80,000 atom system, which is an aquaporine tetramer embedded in a lipid membrane surrounded by water and ions. This is with a two femtosecond time step and it uses PME electrostatics. And there's a larger system. This is a two million atom ribosome benchmarks or ribosome and solution also with PME. And this one uses a four femtosecond time step. So what do we actually really want? So these are our requirements to the hardware sorted by importance. So the most important criterion for us is a high performance to price ratio. But then we also look at the energy consumption, which should be as low as possible. And we also like what to have low rec space requirements because rec space is limited in almost any server room. So we require a packing density of at least one GPU per unit of rec space. So if you have a 4U server with 4 GPUs inside that fits our criterion. And we also like to have a reasonably high performance of each single simulation. So that means with our benchmarks we run one simulation per GPU on the GPU nodes. Or if we just have a CPU node then we run one simulation over the whole node. Of course we could get a higher trajectory output by running let's say 20 simulations on a 20 core server. But that's not a typical scenario. I mean we want to have trajectory production rates that you can really work with. And actually so this best resembles how the cluster then in the end is actually used. Let's quickly look at some, well maybe boring details, but some details about the benchmarks. So I should say all is done with Gromix version 2018 here. We use two combinations of GCC and CUDA. The older benchmarks have been done with an older GCC and CUDA combination. They were typically slower by two and a half percent, but we took that into account. So we re-normalized those so that we have really comparable results for all of the benchmarks that we did. We chose the optimal CMD instruction for at compile time for all the CPUs that we were looking at. OpenMP is of course enabled on nodes with multiple GPUs where we run multiple simulations. We use Intel MPI 2017. And so the important thing is that we all of the nodes are booted from a common software image. So on the software side, they're really identical. For the benchmarks, they typically run for a couple of minutes. And we discard the first part of the run from the timing measurements where let's say effects like memory allocation or load balancing will still lead to a lower than average performance. So the performance that we get is really more or less the end performance. If you let them run longer, you will see the same performance results. One important thing. So on multi-GPU nodes, the benchmarks use one simulation per GPU via the Gromix multi-deer command line switch. And we report the node performance as a sum of the performances of the individual simulations. We call that the aggregate performance. So if we have four simulations producing trajectory at the same time on the four GPU node, then of course the aggregate performance is the sum of the four individual performances. Okay, let's quickly look at the main result of the 2014 hardware evaluation. Maybe I should spend a minute or so to explain these plots that we see quite often in the remainder of the talk. So this is a log-log plot. It shows the simulation performance on the x-axis as in it shows the total hardware costs on the y-axis. So this is for the membrane benchmark system here. And we see results for three different types of nodes. So the yellow circuits show results from just CPU nodes. The green ones are nodes with consumer GPUs and the magenta ones are nodes with professional Tesla GPUs. And an important feature are these white lines here. So these are iso lines of identical or equal performance to price. So the performance to price ratio along this line is the same. And if we move from one line to the next, there's a factor of two in between them. And the best configurations with the highest performance to price ratio are found in the green region. And we see that all the nodes with consumer GPUs, so GeForce GPUs, they are among the best in performance to price. And they produce on average two to three times as much MD trajectory per invested euro compared to CPU nodes. So let's now look at the hardware and software developments during that time. So on the hardware side, mainly developments on the GPU side have taken place. So the single precision floating point based GPU processing power has more or less tripled during that time. So you see the 2014 GPUs in black here, 2016 models here and 2018 models here. And the professional Tesla and Quadro GPUs here in magenta. So but in addition with with other micro architectural improvements that made GPUs better suited for general purpose compute, this led up to six times performance increase in the GPU kernels. So if we measure the throughput, grommets throughput of the GPU kernels. So this is actually a very good indicator for the GPU performance in grommets. So this has seen in six fold increase over that time. So why we see that the raw performance and the throughput is about comparable for the strong Tesla models and the consumer GPU models when we now look at the prices since the price tag is completely different. We find out that the performance to price ratio is completely different. So the professional Tesla GPUs, they can compete with consumer GPUs in terms of performance, but they cannot compete in terms of performance to price. So there's a factor of 10 or so difference here in performance to price. Okay, now let's look at the software developments or at least at these software developments that had a large impact on the grommets performance. For that, let's look at a very simple sketch of what happens during an MD time step. So we see the length of the time step here indicated by the black arrow and the different colored boxes are what typically happens in MD time step. So this is a serial time step, nothing is parallelized yet. So usually you do some kind of peer search or neighbor searching first because you want to compute the interactions of atoms that are within some kind of cut-off radius of another atom. So these are the short-range non-bonded interactions. So after neighbor searching, you have the neighbor list, you can compute the short-range Coulomb and van der Waals interactions. Then normally you have treatment of the long-range part of the Coulomb potential and forces that is usually done by PME. The bonded forces have to be calculated and once all these interactions have been calculated, the velocities and the positions can be updated. Since grommets version 4.6, there is the possibility to offload this blue box, the short-range non-bonded forces to a GPU. And by that, the length of the time step is significantly reduced and thereby of course the performance is a lot higher. So the only thing that you have to pay extra to be able to do that offloading is to have some communication between CPU and GPU, which is symbolized by the gray boxes here, so you need to send the positions of the atoms to the GPU. When the GPU is finished with its calculations, it sends back the forces to the CPU, which can then do the update. So there are two important features for higher performance with GPUs in 2018. One is dual pair lists with dynamic pruning and the other is PME offloading. So let's first look at the dual pair lists. What does that mean? So during pair search, you determine all the neighbors of an atom for which you need to calculate the interactions. So you build a neighbor list and with a very simple neighbor list, you would have to rebuild the neighbor list at every step because you don't know whether some of these atoms that are outside the cut-off radius might have moved inside during that integration step. This is of course a very naive way to do that. So what you usually do is you use a buffered pair list. So that means if you do neighbor searching anyhow, you add a small buffer region for which you don't need to calculate the interactions yet. But if atoms move from the buffer region into the blue region here where you need to calculate the interactions, you already have them in the neighbor list. So that means you can do neighbor searching far less often. So here in fact about every 25 or 50 steps you need to do it. And since version 2018, the dual pair lists were introduced, which means you take that even one step further. So you now have an outer list, which is the light green one here and an inner list, which is the green one. And so you only every very ink frequently build the outer list from all of the atoms and you build the inner neighbor list from the outer neighbor list. And that means you get lifetimes for the outer list of 100 to 200 steps and lifetimes of 5 to 15 steps for the inner list. You don't get extra interactions to calculate because you dynamically prune everything which is outside of your list, which you already know what you don't need to calculate. So by building these lists so less often, the time step is significantly reduced. So the average time that you spend in pair search per step is a lot shorter. And this pruning to get from the outer list to the inner list with GPUs, this is actually for free. Because it can happen at the time when the CPU is anyhow doing the update. So this is happening during a time when the GPU would be idle anyhow. The other important feature of Gromix 2018 is the possibility to also now offload the PME calculations to a CUDA enabled GPU and thereby again significantly reducing the time step if a strong GPU is present. So with PME offloading you have very much less compute demand on the CPU side. And the optimal hardware balance has shifted even more towards the GPU. And this as we'll see will enable higher performance to price ratios if you use cheap GPUs. Let's quickly look at the evolution of the Gromix performance across the releases from 4.6 to 2018 on GPU nodes. So let's take a typical case here with a JETX 1080 GPU and we see that all the releases, the Gromix performance has more or less continually increased. But we see the most pronounced increase in performance when PME offloading is actually switched on. So the blue and the black one are both Gromix 2018. The blue one calculates PME on the CPU and the black one calculates PME on the GPU. And here with a strong GPU you see an almost a factor of 2 gain in performance. Another effect is that of this PME offloading if you look at the performance as a function of CPU cores per GPU. So here we see the number of cores. Let's just look at the left plot, which is the membrane benchmark. The ribosome benchmark is very similar. So we see the two cases. So the dashed lines is when PME runs on the CPU and the solid lines is when PME runs on the GPU. And there's only one case here when it's actually faster to run PME on the CPU. And that is if you have a very strong CPU with 16 cores or 32 threads, it's slightly faster to run PME on the CPU. But in all other cases it's faster to run PME on the GPU. And you see that if you don't aim for the maximum performance on a node that you can get, but just at 80% of the maximum performance, you see that with PME offloading you need far less cores, in this case about 4 to 6 cores, to reach more than 80% of peak performance. And that means that you could translate that into about 10 to 15 core gigahertz suffice with a mid to high-end GPU. So these are CPU cores times CPU frequency. So you would ask, okay, why stay in this yellow region, 10 to 15 core gigahertz? Why not move over to the right? The performance is higher there. But now imagine you have a workstation with 8 cores and 1080 GPU here. And now you want to invest some money and somehow get to some higher performance. What you could do is you could adjust by a second CPU. So more CPU cores, double the number of CPU cores, then you would move along the red line here. But you would only get a slightly higher performance out of that. However, what you could also do is you would invest the money in a stronger GPU. This would instantly give you this amount of higher performance. But what you could also do is you just buy a second GPU, plug it in, and for a single simulation you would move along the green line here. But you would get an aggregate performance of two times that simulation performance. So all together with the second GPU you get the highest aggregate performance from that node here. So yeah, it's better to actually stay in this range because it's simply from a performance to price point. You'll get more out if you run each simulation with just a couple of CPU cores instead of lots of CPU cores. So here we're looking at the main result of our current investigation. So this is the performance in relation to the node costs. I understand that this is a quite complicated plot, but we're going to walk through that and look at the individual features one at a time. So what do we see here? We see again performance on the x-axis, node costs on the y-axis. Again, these are lines of equal performance to price. So the best configurations are in the lower right corner. And we see two benchmarks now. So this is the results of the ribosome benchmarks. These are the stars. And the circuits are the results of the membrane benchmark. So the highest per node performance we find for these high-end Intel CPUs combined with NVIDIA's top-end GPUs, the V100. However, if we look at the performance to price ratio, so if we follow these gray lines down here, this is only slightly better as CPU nodes. So the CPU nodes are the open symbols here. If we look at nodes with consumer GPUs that are the filled symbols, they have a way higher performance to price ratio. So since all of the configurations down here with the consumer GPUs, they are way cheaper than just a single Tesla V100 GPU. So we're going to cut for now the plot about here and just look at the configurations with consumer GPUs. So that looks like this now. We might now ask, okay, what is now the performance to price ratio of consumer GPU nodes with respect to CPU nodes? This depends a bit on actually the configuration if you put in two or four GPUs. But the factors range between three times better, up to seven times better in this case for the epic with four GPUs. So there is a huge gap in performance to price between CPU nodes and consumer GPU nodes. Okay, what are the best or which configurations give the best performance to price ratio? There's quite a few of them, but I've highlighted a couple of them here. So both for the MEM benchmark as well as for the RIP benchmark. So for example, a 10 core Intel or a 60 core AMD Ryzen paired with two up to four top end consumer GPUs will give you the optimal performance to price ratio or you can get also similar performance to price ratios, but for lower investment by pairing a four core Intel node with the two RTX 2080 for example that would be here. But these are just a few examples. So if we now compare that with the Gromax 46, then we see that the gap has actually widened a lot. So I mean the gap between the CPU nodes and the consumer GPU nodes. So this used to be a factor of two to three for Gromax 46 and now with PME offloading and the other features it has gotten to a factor of three to seven with Gromax 2080. And other possibility that we have now, so due to this shift from CPU computing to GPU computing, we can actually upgrade old nodes that we still have with recent GPUs. And I've put one example here. So this is an old four core Intel node where we used to run a GTX 680 in them and we would get a benchmark performance of 27 nanoseconds a day. If we now plug in an RTX 2080, we get a factor of 3.4 times higher performance. So this is the light green node here. And you see, I mean we keep the whole node, we just buy a new GPU and the performance to price ratio is still it's dramatically better than everything else here. Here's two other examples. So these are two times 10 core Intel machines. And we plugged in either two GPUs here, 1080Ti or 2018 or even four. And you see that you get about the same performance to price ratio, even at least a factor of two or even three, four, five higher than new nodes. And even from if you look at the total performance, then also the total performances are not worse for these nodes. They are actually in this case even slightly higher than for this professional node. So to sum that up, so we get one leap in performance to price when moving from CPU nodes to consumer GPU nodes. And we can get if we have the possibility and other leap in performance to price by upgrading existing nodes with current consumer GPUs. Okay, let's also now quickly look at the energy efficiency. So we looked at raw node prices until now and now we're going to add the energy costs to the bill. So here we see an example of a few different nodes and we see the costs of the individual components of the nodes. So the x-axis is the net cost in Euro. For example, if we take this node, this is a 10 core node with a 2630 CPU in it. So this is the price of the CPU. Run some disk, board, chassis, everything what you need. And in this case, a 1080 Ti GPU. Here is an example of an AMD server. So we don't know the individual component price, but the whole thing is costs, well, it's a complete price of the server and you can add or we added two or four GPUs. And now we measured the energy consumption and so that we did while the ribosome benchmark was running. And now we take into account our costs for energy and cooling are about 20 Euro cents per kilowatt hour. And so that you see now as these light blue or grayish blocks. So this is energy costs for each year. So if you operate this configuration for one year, the total price would be nearly 8000 Euro. And if you operate it for another year, you would add up these one year blocks of energy. So we calculate with five years of operation. So after five years, the energy costs are actually about as high as the hardware costs or even higher. So you have to pay more for energy and cooling than you invested originally into the hardware. That we now put into relation to the performance of the ribosome benchmark for these different configurations and then we end up with a result like this. So we see for five years of operation, the total trajectory costs including hardware and energy, in this case for the ribosome benchmark and the orange part is the hardware part and the gray part is the energy part. For comparison, I've also put the old results here. So these are old nodes tested with Gromax 4.6 from our old investigation. And in the middle region here, these are newer nodes with Gromax 2018. One thing to note is that if we look at nodes with just CPUs, so these four here, they have the highest trajectory production costs regardless whether we use Gromax 4.6 or 2018. And we can now ask, okay, how much cheaper can we produce trajectory if we plug in GPUs? And this used to be a factor of 0.6 for Gromax 4.6. So if I plug in 170-80 Ti here, then I produce trajectory for about 60% of the costs of running without a GPU. But for Gromax 2018, this has gone down to about 0.3 or 0.4. So GPU nodes also produce trajectory a lot cheaper than CPU nodes. So the lowest part here, the lowest three configurations are actually GPU upgrades. So these are old nodes. These are the same nodes that we benchmarked in the old investigation. And we simply plugged in, ripped out the old GPUs. We plugged in new GPUs. So the hardware price part just reflects the price of the GPUs. But we also see that also from an energy point of view, they are not using more energy or so as the other new configuration. So even these upgrades are also good to do if you're including the energy costs. So these are the configurations that produce trajectory for the least amount of money. So that's what I wanted to say. So to conclude, if you decide to buy new nodes, then in general consumer GPU nodes have a much higher performance or price ratio than CPU nodes. And if you look at the raw node price, this used to be a factor of two to three for older Gromax versions. And now it has grown to a factor of three to seven for Gromax 2018. And if you include energy costs, then still consumer GPU nodes are about three times better in performance than CPU nodes. If you can, what is even better is recycling old nodes. So we saw as a result of this work shifting towards the GPU. And often there's it's not even needed to upgrade the CPU part of a node. So but if you upgrade the GPU, this yields large performance increases. We saw that the optimal hardware balance is about as a rule of thumb of 15 core gigahertz per 2080 or similar GPU. And I should also say that all of these results, they should very well transfer to the newer Gromax version 2019. So there you also have the possibility to also offload the bonded interactions to a CUDA enabled GPU, which will move the hardware balance even slightly more towards the GPU. And 2019 will also offer PME offloading with OpenCL. So that means you can also use it together with AMD GPUs. There's some additional material I wanted to point out. So if you want to do your own benchmarks, we put our input files on this webpage here. So you can test with your own hardware if you like. And yeah, these are just mentioned publications. There's also a summary poster about the investigation. And with that, I want to thank the Department of Theoretical and Computational Biophysics in Döttingen. I would also like to thank the organizers, BioXL and also for funding with SPPXR. And also I'd like to thank Markus and Hermann from the Max Planck Computing and Data Facility who also helped a lot with recycling nodes. Yeah, thank you all for your interest. And I'm happy to answer any questions. Thank you, Karsten. It was a very interesting talk. A great follow-up on your previous work. We have a question by Horacio. Let's see if we can have an audio link. Horacio, can you hear us? Hello? Yes, we hear you. Yeah, it was during the explanation of this dual air lists with dynamic running. I was wondering if this is just a tuning the skin length at the end. But I think there is another functionality because at the end you explained something with the GPUs. I didn't really understood. But these dual lists are interacting with each other. So basically the idea is that you have an inner list and you don't need to build the inner list again all of the time from all the atomic positions of the whole system, but you just built the inner list from the outer list. So this is far faster. Plus you can do it on the GPU while the CPU does the update. And so the main effect that you see is that you do the pair searching a lot less often. So you only do it every 100 to 200 steps. That is indicated by the smaller green pair search box in this picture, C, compared to the B picture where you need to rebuild the list every 25 or so steps. So you want to do the pair searching as less often as possible. That's the idea. Okay, but if you at the beginning of the simulation just tuned the skin length, it wouldn't be like a similar effect? Well, it depends. You mean you would just from the very beginning you would use a very large buffer, right? Yeah, I mean to tune the buffer to the physics underneath or the system you are tackling. I mean it depends also on the system at the end. I mean the buffer you need anyhow so you don't miss any action. The question is how big is the buffer? Yeah. So you don't want to... So this goes with volume, right? So if you make the buffer a little bit larger then you suddenly have a lot of atoms more in your neighbor list. Therefore it's important to have this pruning that you frequently reduce from this outer list to an inner list which is actually smaller because you don't want to run or compute all the interactions of the outer list. That would be far too many. Okay, I get the idea. So I think it's a bit maybe this tuning skin length procedure but on top of that the pruning part is the dynamic pruning part. It's what you explained that it's making more efficient, let's say. Yeah. Okay, now I got it. Thank you. Then we have a question by Gaia. Just a second. So Gaia, do we hear each other? It's very faint to your voice. Can you speak louder and maybe closer to the microphone? Okay, now. Better? Yes, okay. Thank you. First of all, thanks for the seminar. Then I have a question about, I mean, these results are for a single precision. Sorry for that. Like the benchmark that you show. As for Gromax compiled in single precision? Yeah. Yeah, mixed precision as we say, yeah. Okay. Do they change if you compile Gromax in double? Oh, okay. If you need to run Gromax in double precision, in contrast to mixed precision, then you, I mean, yeah, basically you need to run on a CPU. So there's no version yet that runs. Okay, I see. It was also with all the version. Okay, so it's still double. That's still the case, yes. Okay, thank you. Okay, thank you. Okay, thank you. Okay, I would encourage everyone to use the control panel to ask questions. It's showing the slide here. Rosson. Yes. Our note here. So although I cannot type in a question, I have a question that I would like to ask. Yes. Let's go ahead. So, so Karsten, the multi-TPU results we present, get the performance figure for multi-TPU notes by aggregating figures for a single simulation running on each GPU. How do you think that the results would differ if you were to do a single simulation multi-TPU? So there's, yeah, there's two effects here. So one effect is that, so PME at the moment can just run on a single GPU. So you are, sometimes you're a little bit limited in scaling across the whole node if you have many GPUs because all the PME interactions have to run on one of the GPUs for the moment. And so that's one effect and the other effect is that you, yeah, I mean you're losing or you're lower with parallel efficiency anyhow if you scale across more CPU cores and more GPUs. So if you do that, the performance to price ratio will of course be worse for these configurations. And so in fact, so our motivation for testing one simulation or for benchmarking one simulation per GPU is actually that we didn't want to penalize hardware or let's say you have a node with specific CPU and one GPU and you get the benchmark result and the performance to price ratio and now suddenly there's another vendor who sells the same thing but just he puts two CPUs and two GPUs of the same type on a single node. If we now benchmark one simulation per GPU we get exactly the same performances per simulation and the same performance to price ratio if the price is two times of the single simple node but if we then suddenly benchmark one simulation across the doubled hardware we will also see a reduced performance to price ratio because we have the loss and parallel efficiency and all that and we didn't want that because we didn't want to penalize the aggregation of hardware because that's actually what we want. We want to have as dense hardware as possible in our compute center. Does that make sense? Yes, that makes sense. Thanks very much. Thank you. We have a question by R.K. Let's see. Okay. So actually he's just congratulating Karsten and the whole crew on helping us getting the biggest bang for our buck since 2014 original article. Super helpful. Thank you. This is feedback to Karsten. Yeah, he doesn't have a microphone. He can't say it. So we don't have other questions but well I guess we can expect another update on the work in four years time or something. Yeah, maybe. So what's the new hardware comes up and what new algorithms implement to utilize them better? Yeah, what's all that page? Yeah. And we'll do a follow up webinar on it. So, Karsten, can you show the next slide? Yeah, sure. Thanks. So with this we will finish today's presentation and I would like to remind those of you who are interested in enhancing your simulations with additional functionality. Some of you already know about one popular plugin called Plunt. And we'll have the pleasure to host one of the developers presenting it next week in our Biaxel webinar series. It will be also Thursday from 3 p.m. So you can register for the webinar in the same way as you registered for this one. And we look forward to meet you then. So thank you again everyone for attending and thanks Karsten again for the great work. Thank you for this presentation. Thank you. Bye, have a nice day. Goodbye. Goodbye. Goodbye. Thanks.