 This engineering lab is involved in basic and technological research aimed to realize three-dimensional smart materials for regenerative medicine application, and in particular for articular tissue repair. To release both the internal architecture from macro to nano-scale and the chemistry of such materials have to be finally investigated. Both natural and synthetic polymers have been studied and adopted to realize 3D porous graphs. Different innovative manufacturing procedures have been also tested, like fist drying, elitro-spinning, foaming, and stereolithography. Moreover, as bioengineer, I'm interested on the modeling of the scaffold's geometrical and structural features in order to understand how cells decorate the chemical-physical cues provided by the scaffold itself. The laboratory of tissue engineering consists of about five, seven researchers including master students, PhD, and technicians. The whole work in the lab is highly interdisciplinary and does the team cover skills in different fields, such as bioengineering, material science, biotechnology and physics. The lab contains several instruments including chemical hoods, centrifuges, and the storage equipment for biomaterial preparation. The lab is also equipped with optical scanning and atomic force microscopes, where I observe both material prototypes and engineered new reform tissues. Additionally, we have access to the cell culture facilities and animal factory for biological testing. In this paper, published by International Journal of Biotechnology and Bioengineering, we present a theoretical model of a normal scaffold geometry for control applications. In particular, we have implemented this model with the aim to predict the effect of some genetic parameters on total porosity, mechanical properties and permeability of the graft. This model has been also adopted to produce porous polytapolacton-based graft for contract tissue engineering application, best unique mechanical and functional features of the scaffold. Material prototypes were produced with an internal geometry with parallel-oriented cylindrical pores, resembling the anatomical structural condosides column, besides controlling blood vessel invasion through a limited pore interconnection. The scaffolds have been extensively characterized, and progenitor cells were used to test their capability to support cartilaginous matrix deposition in vivo. Scaffold prototypes showed interesting condrogenic potential besides offering adequate mechanical performances, thus becoming a promising candidate for control tissue repair, which still represents a serious and widely diffused clinical problem. A very good agreement was found between the prediction of the theoretical model and experimental data. Moreover, many assumptions of this theoretical model, here we applied it to cartilage, may be transposed to higher tissue engineering application, such as the substigents.