 The study found that all tested mitochondrial respiratory chain subunits were significantly overexpressed in subjects with Parkinson's disease compared to normal controls, suggesting a possible degeneration-related alteration of the mitochondrial structure and or dynamics or a compensatory mechanism. The study also suggests that studying specific mRNA by peripheral blood mononuclear cells may provide a further diagnostic frame for early detection of PD patients. This article was authored by Michelle Salemi, Filomena Cosentino, Giuseppe Lanza, and others.