 One Health is an interdisciplinary perspective that recognizes the interconnectivity of all life systems on planet Earth. The footprint of all living things overlap like a Venn diagram. The health of humans, animals, and the environment are inextricably linked, and stressing one life system impacts them all. So what efforts can be made to promote global health and well-being? To diminish the domino effect of negative impact, it is pivotal that we manage issues and minimize unintended consequences before they spiral out of control. For example, warmer temperatures worldwide have caused an increase in mosquito populations, which thrive in hot climates. Rather than a 30- to 40-day gestation period, mosquitoes become full-grown in just six days, leading to rapid population growth, and warmth causes a greater rate of transmitting infections during their lifetime. The spread of infectious disease is one of the primary focuses of One Health. 75% of emerging diseases in humans can be traced back to wild animals. The Ebola virus in bats, for example, is considerably distanced from most human life. But in a scenario where an infected bat contaminates fruits, which are consumed by monkeys that are later hunted by humans, we can easily have an outbreak on our hands. Preemptively treating wild animals would remove the risk to domestic animals and humans alike. Shifting the paradigm upstream helps control and prevent disease transmission and demonstrates the need for a unified One Health approach. It's important that all disciplines and spheres become aware of their impact on other life systems on Earth. By enhancing cooperation between health and environmental professionals, communicating issues and goals with political leaders, and educating the public sector, we can achieve the best health outcomes for all of Earth's living creatures. Let's join efforts to act responsibly and positively impact global health. Start today with One Health.