 Cancer stem cells, CSCS, are small population of cancer cells that have the ability to self-renew and differentiate into multiple types of cells. They are thought to be responsible for tumor initiation, progression and metastasis. CSCS are able to adapt to the environment around them, which allows them to survive even when exposed to chemotherapy and radiation. This makes them difficult to eradicate completely, resulting in tumors returning after treatment. CSCS also play a role in angiogenesis and metastasis, two processes that allow cancer cells to spread throughout the body. Understanding how CSCS behave and interact with their environment could lead to new treatments that target these cells specifically. This article was authored by Ayn Zubayda Iyob and Tamil Selvi Ramasamy.