 I can do slightly better that hand waving when it comes to saying how fast the helix folds. You remember your kinetics. The tau it would take to form a helix is, again, roughly proportional to some sort of time constant for the fundamental processes and that would basically be forming a hydrogen bond that happens in a nanosecond or so, multiplied by exponential raised to plus the barrier, right? But that barrier should now be f in it, divided by kT, where in it is the barrier for initiating the alpha helix formation. But that is the energy that we would take to start it at one specific residue. If we have N0 residues in the chain, there are N0 different points where that can happen, right? And from the last slide, you saw that N0 was roughly proportional to e raised to plus f in it, divided by 2 kT2. So we should divide the time by that. So time helix anywhere is roughly proportional to tau. Well, this is just going to be the logarithm loss. We'll have a factor of 2 in the denominator instead. e raised to plus f in it, divided by 2 kT there. Do the math. We're going to take f in it and when we divide by this, that means subtracting the value of that exponent here. So f in it by kT minus f in it divided by 2 kT leaves the other half f in it by 2 kT. But we also knew roughly what the f in it here was. The f in it was in the ballpark of say 4 or 5 kcal divided by 2 kT. And the tau process here was in the ballpark of say a nanosecond. Again, order of magnitude estimates. This factor is going to be say 500 to 1000. So that would mean that we predict that helices would form again in the ballpark of a microsecond. And that actually works quite well. The fastest helix formation might be in the ballpark of 100 nanoseconds. And the smallest one might be factor 100 or so slower. So even the super simple estimated kinetics rate turned out to serve exceptionally well. The other thing that I think this shows is that don't sweat the factors of 2. Because if I get things right within an order of magnitude here, that error is likely going to be lower than the estimates we have for assault concentrations, the amount of protein, the length of the chain, etc. There are many factors we're ignoring here. But this is about understanding. And when we get to beat that, sheets in particular, you will show that the important thing here is going to be to understand the differences that corresponds to 5 or 10 orders of magnitude, not the factor 10.