 This study has identified a new mechanism by which colorectal cancer, CRC, can spread to the liver. It found that CRC cells released two key factors, VECF and Illinois 6, which stimulate the liver's own cells, called hepatic stellate cells, HSCs, to transform into cancer-promoting cells known as carcinoma-associated fibroblasts, CAFs. This process allows the cancer to spread more easily to the liver. Additionally, this study discovered that a natural compound called Brevillein A can block this process, thus preventing the spread of CRC to the liver. These findings suggest that Brevillein A could be developed into a new type of drug to treat metastatic colon cancer. This article was offered by Shweing Fan, Ming Jing Meng, Bao Ting Li, and others.