 Bioactive glasses have had a significant impact on the field of regenerative medicine. Invented by Larry Hench in 1968, the original 45S5 glass composition has been used in millions of patients worldwide to treat bone and dental defects. Since then, numerous other bioactive glass compositions have been developed and tested for various medical applications, including soft tissue repair and drug delivery. Despite these advances, there is still much to be discovered and explored. This paper reviews the current clinical applications of bioactive glasses and identifies six key areas of focus for future research. It is hoped that this review will serve as a guide for early-stage researchers and experienced scientists alike, encouraging further investigation into the potential of bioactive glasses in medicine. This article was authored by Francesco Baino, Sapita Hamzala, and Saeed Kargozar.