 The study aimed to assess the clinical severity of plaque psoriasis in Brazil and evaluate potential associations between disease severity and demographic, lifestyle, and clinical characteristics, health-related quality of life, HRQL, and work productivity among 11-25 patients. The results showed that 205-18.2% had moderate to severe disease, with psoriasis severity being significantly associated with physical inactivity, comorbid pain, anxiety, depression, HRQL, and work productivity, while being inversely associated with BSA. However, cross-sectional studies have limitations that cannot assess temporal trends or conclusively determine causality or exclude biases and confounding due to unmeasured variables. This article was authored by Ricardo Ramiti, Lincoln Helder Zambaldi Fabricio, Casilda D.A. Silva Souza, and others.