 The importance of satiety is underscored by a rare genetic condition known as Prader-Willi syndrome. Children with the disorder are born with impaired signaling between their digestive system and their brain, so they don't know when they're full. With no sensation of satiety, they can accidentally eat so much they fatally ruptured their stomach. Without satiety, food can be a death sentence. Protein is often described as the most satiating macronutrient. People tend to report feeling fuller after eating a protein-rich meal compared to a carbohydrate or fat-rich one. The question is, does that feeling of fullness last? From a weight loss standpoint, satiety ratings only matter if they end up cutting down on subsequent calorie intake. And even a review funded by the meat, dairy, and egg industries acknowledged that this does not seem to be the case for protein. Hours later, the protein consumed earlier doesn't tend to end up cutting calories later on. Fiber-rich foods, on the other hand, can suppress appetite and reduce subsequent meal intake more than 10 hours later the next day because its site of action is 20 feet down in the lower intestine. Remember the illegal break from my evidence-based weight loss lecture? Secretly infused nutrients into the end of the small intestine and people spontaneously eat as many as hundreds of fewer calories at a meal. Our brain gets the signal that we're full from head to tail. Remember, we were built for gluttony. It's a hedge against times of scarcity. Stumbling across a rare bounty, those who could stuff themselves the most to build up the greatest reserves would be more likely to pass along their genes. So we are hardwired, not just to eat until our stomach is full, but until our entire digestive tract is occupied, only when our brain senses food all the way down at the end as our appetite fully dial down. Fiber-depleted foods get rapidly absorbed early on, though, so much of it never makes it down to the lower gut. So if we're eating low fiber, no wonder we're constantly hungry and overeating, our brain keeps waiting for the food that never arrives. That's why even people who have stomach-stapelink surgeries, leaving them with a tiny two-tablespoon-sized stomach pouch, can still eat enough to regain most of the weight they initially lost. Without sufficient fiber, transporting nutrients all the way down our digestive tract, we may never be fully satiated. As I described in my last video, one of the most successful experimental weight loss interventions ever reported in the medical literature involved? No fiber at all, though. What was going on with that? In the first glance, it might seem like a no-brainer that removing the pleasurable aspects of eating would cause people to eat less. But remember, that's not what happened. The lean subjects continued to eat the same amount, taking in thousands of calories a day of the bland goop. Only those who were obese dropped from eating thousands of calories a day down to hundreds. This happened inadvertently, without them apparently even feeling a difference. Something after eating was disconnected from the reward was the body able to start rapidly raining in the weight. See, we appear to have two separate appetite control systems, the homeostatic system and the hedonic system. The homeostatic pathway maintains our calorie balance by making us hungry when energy reserves are low, and abolishes our appetite when energy reserves are high. In contrast, our hedonic or reward-based regulation can overwhelm our homeostatic pathway in the face of highly palatable foods. This makes total sense from an evolutionary standpoint. In the rare situations in our ancestral history, when we'd stumble across some calorie-dense food like a cache of unguarded honey, it would make sense for our hedonic drive to jump into the driver's seat to gobble up the scarce commodity. Even if we didn't need the extra calories at the time, our bodies wouldn't want us to pass up that rare opportunity. Such opportunities aren't so rare anymore, though. With sugary fatty foods around every corner, our hedonic drive may end up in perpetual control, overwhelming the intuitive wisdom of our bodies. So, what's the answer? Never eat really good-tasting food? No, but it may help to recognize the effects hyper-palatable foods can have on hijacking our appetites and undermining our bodies' better judgment. Ironically, some researchers have suggested a counter-balancing evolutionary strategy for combating the lure of artificially concentrated calories, just as pleasure can overrule our appetite regulation, so can pain. Conditioned food aversions are when we avoid foods that made us sick in the past. That may just seem like common sense, but it's actually a deep-seated evolutionary drive that can defy rationality. Even if we know for a fact a particular food was not the cause of an episode of nausea and vomiting, our body can inextricably tie the two together. This happens, for example, with cancer patients undergoing chemotherapy. Consoling themselves with a favorite treat before treatment can lead to an aversion to their favorite food if their body tries to connect the dots. That's why oncologists may advise the scapegoat strategy of only eating foods before treatment you're okay with never wanting to eat again. Researchers have experimented with inducing food aversions by having people taste something before spinning them in a rotating chair to cause motion sickness. Eureka, a group of psychologists, suggested this kind of strategy as a way of encouraging people to eat less unhealthy food, make them sick of the food by making them sick from the food. Or hey, what about using disgust to promote healthier eating? Children as young as two and a half years old will throw out a piece of previously preferred candy scooped out of a brand new sparkling clean toilet bowl. Thankfully, there's a way to exploit your instinctual drives without resorting to revulsion, aversion, or bland food, which we'll explore next.