 One, lipid-based drug delivery systems, specifically solid lipid nanoparticles, excellence, and nanostructured lipid carriers, NLCS, have gained attention due to their ease of manufacturing, scale-up capability, biocompatibility, and biodegradability. Two, these delivery systems offer advantages related to specific routes of administration or the nature of materials being loaded, making them effective in drug delivery. Three, the article aims to review the advantages and limitations of these delivery systems based on their route of administration and emphasize their effectiveness.