 This paper highlights the growing use of social media by researchers to engage in public debates and rapidly disseminate research results, specifically focusing on TikTok's unique potential for collaborative knowledge mobilization with underserved communities who experience barriers to health care and health inequities. The paper presents analytics data from 13 selected TikTok videos on the topic of research on gender-affirming medicine to illustrate how knowledge is disseminated within the trans community via TikTok, while also discussing considerations for researchers planning to use TikTok for digital knowledge mobilization and other related community engagement with equity-seeking groups. The paper concludes that TikTok presents possibilities for achieving transformative, community-engaged knowledge mobilization among researchers, underserved health care users, and their health care providers. This article was authored by Kinan Ross McKinnon, Hanakia, and Ashley Lacombe Duncan.