 This study demonstrates the potential of using an organ on a chip, OC, platform with a transendothelial electrical resistance, TER, measurement system to assess the permeability performance of targeted gold nanorots, GnR, fortheronostics of Alzheimer's disease. The GnR, PEG, and 2D1 nanoformulation was found to be safe and effective for crossing the blood-brain barrier, BBB, and could potentially be used for treating Alzheimer's disease. This article was authored by Suji Parmaflores, Adrienne Lopez-Gnoza, Francisco Moales-Savola, and others.