 The disproportionate burden of chronic diseases among African Americans coupled with low flu vaccine uptake is due to individual attitudes and beliefs, social norms, and healthcare practices. Recent research identifies critical factors affecting vaccine uptake among African American adults, including perceived risk of side effects, lack of social support for vaccination, and lower knowledge of the flu and vaccine. However, there is substantial trust in physicians about the flu vaccine and a strong recommendation from providers can increase seasonal flu vaccination among African Americans.