 This study developed a novel photothermal nanoparticle-loaded tumor cell vaccine, TCV, platform that can be used to treat various types of cancer. The TCV platform consists of photothermal nanoparticles loaded onto tumor cells, which are then injected into the body. When exposed to near-infrared light, the nanoparticles release heat, which causes the tumor cells to express heat shock proteins as endogenous adjuvants. These heat shock proteins activate dendritic cells, which in turn stimulate the immune system to fight off the tumors. Additionally, the researchers found that the TCV platform could be used to manipulate the immune system on demand, allowing for the precise timing of the treatment. In animal studies, the TCV platform was able to reduce tumor size in multiple mouse models, including those based on humanized mice and patient-derived tumor xenographs. This article was authored by Jiaqi Meng, Yanglin LV, Waiyabao, and others. We are article.tv, links in the description below.