 PIK5 is an important protein involved in the regulation of metabolism and mitochondria health. It has been shown to be essential for maintaining normal heart function and preventing cardiomyopathy associated with obesity. Studies have found that inhibiting PIK5 can reverse the effects of obesity on the heart, such as mitochondrial damage and hypertrophy. This suggests that PIK5 could potentially be used as a therapeutic target for treating obesity-related cardiomyopathies. This article was authored by Helen Trancheer, Muchu Sinato, Andrei Timitin, and others.