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Arginine Glycine Aspartic Acid Motif Peptide Potentiates the Effect of Oxaliplatin





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Published on May 2, 2012

Arginine Glycine Aspartic Acid Motif Peptide Potentiates the Effect of Oxaliplatin Preventing Colon Cancer Metastasis, Binds to α5 β1 Integrin and Suppresses FAK/ERK/NF-kB Signaling

Friday, April 6, 2012 • 11:00-11:15 AM

Authors: Elvira de Mejia*, and Vermont Dia

Lunasin is a promising chemopreventive agent. The objective was to study the effect of lunasin on human colon cancer metastasis using in vitro and in vivo colon cancer model of liver metastasis. Lunasin inhibited the activation of focal adhesion kinase by 28%, 39% and 60% in RKO, HCT-116 and KM12L4 human colon cancer cells, respectively. Lunasin caused an increase in the expression of the inhibitor of kappa B alpha, a decrease in nuclear p50 NF-kB and a reduction in the migration of cancer cells. Lunasin inhibited metastasis and potentiated the effect of oxaliplatin by reducing the expression of proliferating cell nuclear antigen. Liver metastatic nodules were reduced from 28 (PBS) to 14 (lunasin, p = 0.047) while combination of lunasin and oxaliplatin to 5 (p = 0.004). The tumor burden was reduced from 0.13 (PBS) to 0.10 (lunasin, p = 0.039) to 0.04 (lunasin-oxaliplatin, p less than 0.0001). The effect of oxaliplatin in modifying the expression of proteins involved in apoptosis and metastasis was potentiated by lunasin. Lunasin inhibited metastasis by direct binding with alpha-5 beta-1 integrin suppressing FAK/ERK/NF-kB signaling, and potentiated the effect of oxaliplatin in preventing the outgrowth of metastasis.


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