 This study found that alpha-lipoic acid improved the activity of peroxinase 1, PON1, in diabetic rats, leading to lower levels of triglycerides, total cholesterol, low-density lipoproteins, very low-density lipoproteins, atherogenic index, atherogenic coefficient, and cardiac risk ratio. Additionally, it was observed that PON1 activity was positively correlated with high-density lipoprotein, HDLC. These findings suggest that alpha-lipoic acid may be beneficial in reducing the risk of coronary artery disease and atherosclerosis in diabetic patients. This article was authored by Parisa Jammer, Hassan Ahmedband, Mehdi Perjandi, and others.