 In-vitro tumor models have provided important tools for cancer research and serve as low-cost screening platforms for drug therapies. Cancer recurrence remains largely unchecked due to metastasis, which is the cause of the majority of cancer-related deaths. Advances in tumor cell biology, 3D cell culture, tissue engineering, biomaterials, microfabrication, and microfluidics have enabled rapid development of new in-vitro tumors models. This article was authored by Mariah E. Katt, Amanda Iplacone, Andrew E. Wong, and others.