 This systematic review examines the scientific basis for Canada's physical activity guide for healthy active living for adults, specifically focusing on the dose response relationship between physical activity and premature alka's mortality in seven chronic diseases, cardiovascular disease, stroke, hypertension, colon cancer, breast cancer, type 2 diabetes, and osteoporosis. The review identifies a total of 254 articles that met the eligibility criteria related to these health outcomes. Overall, the current literature supports the dose response relationship between physical activity and these chronic conditions, with higher levels of physical activity reducing the risk for premature alka's mortality. The Canadian guidelines appear to be appropriate to reduce the risk for these chronic conditions and alka's mortality. This article was authored by Ivy Adam, Charles Worth-Sara, Warburton-Darren-ER, and others.