 Skin cutaneous melanoma, SKCM, also known as melanoma, is the most deadly type of skin cancer, with increasing incidence rates. Regulated cell death plays an important role in tumor genesis and is a key target for many treatments. Cuproptosis is a newly discovered form of cell death that requires mitochondrial respiration. Its role in tumor genesis is still unclear. To explore this, we accessed a public database and found that 11 out of 12 genes related to cuproptosis are overexpressed in melanoma tissue samples. Three genes, LIPT1, PDHA1, and SLC31A1, were found to be predictive of patient prognosis. Patients with higher levels of these genes have better overall survival than those with lower levels. We then focused on LIPT1, which was positively correlated with PD, L1 expression and negatively associated with TREG cell infiltration. Melanoma patients with higher LIPT1 expression had longer overall survival when treated with immunotherapy, suggesting that LIPT1 may be a useful prognostic indicator. This article was authored by Haohan LV, Xiaolu, Chuanhao Zeng, and others. We are article.tv, links in the description below.