 The study investigates the role of human umbilical cord mesenchymal stem cell, HUCMSC, derived exosomes in regulating burn-induced inflammation. The results show that HUCMSC exosome administration can reverse the inflammatory reaction caused by lipopolysaccharide, LPS, exposure and reduced tumor necrosis factor alpha, TNF alpha, interleukin 1 beta, IL 1 beta, and increase IL 10 levels. Further studies reveal that MIR-181C in the exosomes plays a crucial role in regulating inflammation by down-regulating the TLR4 signaling pathway. The study concludes that HUCMSC exosomes expressing MIR-181C can effectively alleviate burn-induced inflammation by suppressing the TLR4 signaling pathway. This article was authored by Xiaoli, Lingying Liu, Jingyang, and others.