 Over eons, the temperature of the Earth has changed many, many times. How do living organisms cope with these dramatic changes in climate? What are the challenges we face and how do we use scientific inquiry to solve problems and also to support life on Earth? Everything on Earth is interconnected in complex ways. How do changes in climate affect those connections? And how can we figure out what is reasonable to believe given the large amount of sometimes contradictory information? In this class, we will take a close look at the tools and information scientists have used to reconstruct climate conditions and living system responses. We also will attempt to reproduce some of the results that scientists have reported. Then students will create e-portfolios documenting their discoveries. Climate change biology is a hands-on, online course centered on studying and conducting scientific research to get a better understanding of the amazing adaptability and the limits of ecological systems and living things.