 Atomer nanoparticle-based biosensors are rapidly emerging as powerful tools for detecting a wide range of biomolecules. Nanoparticles offer unique advantages such as high carrier capacity, stability, and enhanced diffusivity, while atomers provide high selectivity, affinity, and reproducibility. Combination of these two technologies provides a promising platform for rapid and sensitive detection of biomolecules. This review discusses the recent advancements in Atomer nanoparticle-based biosensors and compares them according to nanoparticle type and detection mechanism. Additionally, we highlight the strengths and weaknesses of each approach and discuss future directions. This article was authored by Ruiading Su, Leishan Ouyang, Hei Chen, and others.