 mitochondrial contact site and Christy organizing system, MECOS complexes are essential for proper mitochondrial structure and function. Two subunits of this complex, MIC26 and MIC27, have been identified as key regulators of mitochondrial morphology and metabolism. These two subunits are exclusively located in mitochondria and are responsible for the maintenance of mitochondrial structure and integrity. Depletion of either MIC26 or MIC27 results in impaired mitochondrial morphology and function leading to increased oxidative stress and ultimately diabetic complications. This article was authored by Melissa Lubeck, Nick H. Durkham, Ritam Naha and others.