 Graphene-based nanomaterials, GBNs, have become increasingly popular in the scientific community due to their unique physical and chemical properties. These nanomaterials have been used in various biological applications such as drug delivery, tissue engineering, and biosensor development. Despite the growing interest in GBNs, there has not yet been a comprehensive review of their biomedical applications and potential environmental and human health risks. This paper provides an overview of the history, synthesis, structure, and recent developments of GBNs, as well as their use in biomedical applications, including drug delivery, tissue engineering, and biosensor development. Additionally, the paper discusses the potential environmental impacts and human health risks associated with GBNs. Finally, it outlines future directions and challenges for the field. This article was authored by Fabitha P. Dasari Sharina, Danielle McShann, Asak K. Dasmaapatra, and others. We are article.tv, links in the description below.