 Turbium sec is a new technique developed to identify compact ionasecondary structures in large ionase molecules. It uses Turbium-3 ions to induce cleavage at specific locations within the ionase molecule, allowing researchers to identify sharp backbone turns and ionase interactions. By analyzing the resulting sequence data, researchers can gain insight into how ionase molecules fold and interact with each other, potentially leading to a better understanding of how ionase molecules regulate gene expression. This article was authored by Shivali Patel, Alec N. Sexton, Madison S. Strine and others.