 Abstract methylprednisant sodium succinate, MPSS, is a parenteral water soluble corticosteroid ester. It produces three peaks of methylprednisant, Mp17 methylprednisant hemisuccinate, 17 MPHS, and methylprednisant hemisuccinate, MPHS, which can be detected simultaneously. This study developed a rapid RPHPLC method for the simultaneous determination of these compounds in a single run. The method showed excellent linearity, repeatability, sensitivity, selectivity, and low cost. The chromatographic system consisted of RPHPLC using a BDS column, 250 mm X4.6 mm X5 micrometers, with a mobile phase consisting of WFI, glacial acetic acid, a set in a trial, 63,2,35, at a flow rate of 2.0 milliliters per minute and detection at 254 nanometers. The method demonstrated good accuracy and precision with LODs and LOQs of 143.97 nanograms per milliliter and four. This article was authored by Mustafa F. Olhakarni. We are article.tv, links in the description below.