 Monkeypox is a zoonotic disease caused by an orthopox virus that results in a smallpox-like disease in humans. The number of human monkeypox cases has been on the rise since the 1970s, with the most dramatic increases occurring in the Democratic Republic of the Congo, DRC. The median age at presentation has increased from 4 to 21 years, and there was an overall case fatality rate of 8.7%. Since 2003, import and travel-related spread outside of Africa has occasionally resulted in outbreaks. Interaction slash activities with infected animals or individuals are risk behaviors associated with acquiring monkeypox. The appearance of outbreaks beyond Africa highlights the global relevance of the disease. Increased surveillance and detection of monkeypox cases are essential tools for understanding the continuously changing epidemiology of this resurgent disease. This article was authored by Evelyn M. Bunch, Bernard Hote, Liddy Chin, and others. We are article.tv, links in the description below.