 Chronic wounds are a growing problem worldwide due to the aging population and the rising prevalence of comorbidities. These wounds are difficult to treat with existing antibiotics as they are often infected with resistant bacteria. Nanostructured zinc oxide, zeno, has been shown to be effective against a variety of bacteria making it a promising material for use in antimicrobial bionanocomposite and zeno-BNC materials. These composites have been engineered from various preparations including films, hydrogels, and electrospun fibers and have been tested for their antimicrobial properties, wound healing capabilities, and mechanical, water, and gas permeability. Early results show promise, but more research is needed to determine the optimal preparation method and to understand the mechanisms behind the antimicrobial activity of nzeno-BNCS. This article was authored by Paolo Pino, Francesco Bosco, Caramalia, and others.