 The National Centre for Accelerating Clinical and Translational Science and CATS Clinical and Translational Science Award, CTSA, program has been a leader in promoting health equity through its emphasis on community engagement and translational scholarship. CATS provides a comprehensive infrastructure and resources to facilitate a health equity focus to dissemination and implementation, D&I, science. A framework is proposed which illustrates the interaction and opportunities between health equity and D&I science and highlights how CTSA hubs can support and facilitate wider efforts in translational research with a focus on equitable D&I. This article was authored by Risa Yusefineure, Bethany M. Kwan, Elizabeth Kahn, and others.