 The transition from glucose to methanol enhance cellular polymorphous cells results in significant changes in gene expression. Genes involved in methanol metabolism are strongly upregulated, including those encoding transcription factors, formate dehydrogenases, and enzymes of the methanol dissimulation pathway. Additionally, genes involved in peroxisomal oxidation are upregulated, as well as genes involved in autophagy processes. Downregulation of genes involved in transcription and translation suggests that the lower growth rate on methanol compared to glucose may be the cause of these changes. This article was authored by Kipers-Oscopy, De Jong-An, Susanikim A, and others.