 Polymers are widely used in the biomedical industry but require surface modifications before being used in certain applications. For common methods of surface modification include laser treatment, ion implantation, plasma treatment, and nanoparticle grafting. These methods alter the physical and chemical properties of the polymer, its morphology, and its biocompatibility. Mammalian cells can be used to assess the effectiveness of these surface modifications, including mammalian cell adhesion and proliferation. The results of this study suggest that surface modification can improve the biocompatibility of polymers, making them more suitable for use in the biomedical industry. This article was authored by Uldrich Nadeela, Petroslepica, and Voslav Sworsik.