 Abstract biofilms are difficult to treat due to their resistance to antibiotics and other methods. A new phototherapeutic system has been developed using MOS2, IR780 photosensitizer, and RGDC to eradicate biofilms on titanium implants within 20 minutes. This system combines photothermal therapy, PTT, and photodynamic therapy, PDT, with the assistance of glutathione oxidation accelerated by near-infrared light, AR. This combination provides synergistic and rapid killing of bacteria, resulting in 98.99% eradication of a Staphylococcus aureus biofilm in vivo within 20 minutes. Additionally, this system is safe for use as it does not damage surrounding tissue and is biologically compatible. This article was authored by Mouli, Li Chenli, Kuansu, and others.