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Cell Isolation - The Two Worlds of Cell Separation

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Published on Nov 12, 2010

Cell isolation, See REFERENCES below. An entertaining and useful explanation of the differences between the micro- and nano-particle techniques used for cell isolation / cell separation.

Articles from RICE (mentioned in video): http://bit.ly/gPytFD, http://bit.ly/gXo3KY, http://bit.ly/i5i8kI, http://bit.ly/ergkVa

Article by Dr. Shenoy (mentioned in video): http://bit.ly/dLZPqf

Article on cellular responses to dextran-derivatised iron oxide nanoparticles: http://bit.ly/i4BPbQ

Article on uptake of dextran-coated nanoparticles: http://bit.ly/fQEU5d

Article indicating induction of forced cellular iron elimination of nanoparticles: http://bit.ly/i72Nnd

Article on iron oxide nanoparticle toxicity: http://bit.ly/gUTAeu

Article on polystyrene nanosphere toxicity: http://bit.ly/heJWJp

Article on nanoparticle impacts on gene expression: http://bit.ly/fQ58wx

Article on cell response to dextran-derivatised iron oxide nanoparticles post internalization: http://bit.ly/hbhWnH

Article on dextran derivatised iron oxide nanoparticles and their influence on fibroblasts: http://bit.ly/dW1CCy

Article on nanoparticle cytotoxicity and changes in cytokine induction: http://bit.ly/dFdifn

Article on immunotoxicity of nanoparticles: http://bit.ly/dFGkyX and http://bit.ly/ggkhjr

Article on metal oxide nanoparticle toxicity: http://bit.ly/fphwwh

Article on receptor mediated endocytosis of nanoparticles: http://bit.ly/hMk7vM

From the fields of nanomedicine and nanotoxicology: http://bit.ly/gpMsA7, http://bit.ly/cDOxDn, http://bit.ly/gv71Wp, http://bit.ly/frF180, http://bit.ly/fTJTf8, http://bit.ly/17wHLO

Journal dedicated to nanotoxicology: http://informahealthcare.com/nan

More refs: http://en.wikipedia.org/wiki/Nanopart...

The European Commision's initiative on the potential harmful effects of nanoparticles: http://bit.ly/g4gnUo

What level of uncertainty is acceptable? When searching the literature, we find plenty of articles where the use of nanoparticles seem to have no negative effects in a variety of settings. Along with plenty of articles demonstrating the opposite - that nanoparticles do indeed have a detrimental impact.

When will the knowledge and concerns about nanoparticles from the field of toxicology bridge over to the continent of cell isolation?

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