 The classical, standard, approach of RIC curve analysis considers event, disease, status and marker value for an individual as fixed over time. In practice, both the disease status and the marker value change over time. Individuals who are disease-free earlier may develop the disease later due to longer study follow-up. We have also extended some methods to incorporate a longitudinal marker. This article was authored by Audina Narja Kamarudin, Trevor Cox and Rwanti Kola Managedona.