 1. The management of infectious diseases can lead to isolation, which may affect mental health, but the effects are still unknown. 2. We examined the prevalence of anxiety symptoms and anger in individuals isolated during the Middle East Respiratory Syndrome, MERS, epidemic both at the time of isolation and 4-6 months after release from isolation. 3. We also determined risk factors associated with these symptoms at 4-6 months. 4. Of 14,992 individuals isolated for two weeks due to contact with MERS patients in Korea in 2015, 1,692 were included in the study. 5. Anxiety symptoms were evaluated using the generalized anxiety disorder 7-item scale and anger was assessed using the state trait anger expression inventory at 4-6 months after release from isolation from MERS. 6. Among 1,692 who came in contact with MERS patients, 1,656 were not diagnosed with MERS. 7. During the isolation period, anxiety symptoms were observed in 7.6%, 95% confidence interval, CI, 6.3-8.9% and feelings of anger were present in 16.6%, 95% CI, 14.8-18.4%. 8. At 4-6 months after release from isolation, anxiety symptoms were observed in 3%, 95% CI, 2.2-3.9% and feelings of anger were present in 6.4%, 95% CI, 5.2-7.6%. 9. Risk factors for experiencing anxiety symptoms and anger at 4-6 months after release included symptoms related to MERS during isolation, inadequate supplies, food, clothes, accommodation, social networking activities, email, text, internet, history of psychiatric illnesses, and financial loss. 10. Mental health problems at 4-6 months after release from isolation might be prevented by providing mental health support to individuals with vulnerable mental health and providing accurate information as well as appropriate supplies, including food, clothes, and accommodation. This article was authored by Hyun Suk Jong, Hyeon Woo Yim, Young Joon Song, and others. We are article.tv, links in the description below.