 This systematic literature review found that there is a lack of standardization of varicella immunization policies in Europe, including countries in Central and Eastern Europe, CEE. The review identified 26 studies on the epidemiology, health burden, and economic costs of varicella in CEE. Limited information exists on the burden of varicella in CEE due to inconsistent reporting systems. Funded universal varicella vaccination is currently available only in Latvia as a one-dose schedule, but Hungary and Latvia are introducing a two-dose strategy in 2019. Introduction of vaccination in countries that do not provide UVV is predicted to provide substantial reductions in cases and rates of associated complications with important economic benefits. This article was authored by Sofia Messner, Jochek Wysoki, Darko Richter, and others.