 This research proposes a new approach to treating cancer by targeting both the tumor cells and their surrounding environment. The researchers developed a nano-delivery system consisting of a hyaluronic acid, HA, coated with a dipeptide that targets fibroblast activating protein, FAP. This combination allows for precise targeting of cancer-associated fibroblasts, CAFs, and opens up the physical barriers of tumors, allowing for deeper penetration of the drug. Additionally, the nanoparticles are engineered to be sensitive to changes in pH and reactive oxygen species, ROS, which can cause them to break down into smaller particles and release the drug inside the tumor. This dual-targeting system has been shown to be effective against breast cancer cells in vitro and in vivo.