 Colorectal cancer, CRC, is the third deadliest and fourth most common cancer worldwide with nearly 2 million new cases and 1 million deaths expected in 2018. The driving factors behind its growth are obesity, sedentary lifestyle, red meat consumption, alcohol, and tobacco. However, recent advances in early detection screenings and treatment options have reduced mortality in developed nations. Genetic testing and better family history documentation can help those with a hereditary predisposition take preventive measures while the general population can reduce their risk by lowering red meat, alcohol, and tobacco consumption and raising fiber, wholesome food, vitamins, and minerals intake. This article was authored by Prashant Rala, Tagore Sankara, and Adam Barsuk.