 Smart polymers have enormous potential in various applications, particularly in smart polymeric drug delivery systems that can release and trap drugs in response to specific physiological triggers. These polymers exhibit a nonlinear response to a small stimulus leading to a macroscopic alteration in their structure slash properties and the response is very widely from swelling slash contraction to disintegration. Synthesis of new polymers and cross linkers with greater biocompatibility and better biodegradability would increase and enhance current applications. The most fascinating features of smart polymers arise from their versatility and tunable sensitivity but the slow response time is a significant weakness. Development of smart polymer systems may lead to more accurate and programmable drug delivery and various mechanisms by which polymer systems are assembled in situ to form implanted devices for sustained release of therapeutic macromolecules are discussed, highlighting various applications and advanced drug delivery. This article was authored by Honey Pria James, Riho John, Anju Alex, and others. We're article.tv, links in the description below.