 Monte Carlo simulations of generic coarse grain models are used to study the interactions between lipid bilayers and rigid transmembrane proteins. Different protein models are considered and compared, and key parameters such as hydrophobicity and hydrophobic mismatch are varied systematically. The response of the membrane to the insertion of single proteins is found to be mostly generic and independent of the choice of protein model. Orientational distributions of single proteins depend mainly on hydrophobic mismatch and hydrophobicity, with weakly hydrophobic proteins tilting in response to positive hydrophobic mismatch, strongly hydrophobic proteins distorting the surrounding membrane, and intermediate hydrophobicity proteins exhibiting a competition between these two mechanisms. Clusters of strongly hydrophobic proteins with negative positive mismatch may nucleate raft-like structures in membranes, with this effect being more pronounced for proteins with rough, structured surfaces. This article was offered by George Nedder, Peter Nieleba, Pete West, and others. We are article.tv, links in the description below.