 This study investigates the fluctuations in public positivity towards COVID-19 vaccines in China on Weibo, the largest social platform, using pandas and snow NLP Python libraries for sentiment analysis. The results show that public positivity towards COVID-19 vaccines fluctuates over time and is correlated with public health events, gender and region. Policymakers should adjust their policies through positive incentives and prompt responses to pandemic-related news to promote vaccination acceptance. This article was authored by Xi Jinping, Guanrui Feng, Jiahong Su, and others.