 Previous studies suggest that MSG may have a biphasic effect on appetite, increasing it within a meal with its flavor-enhancing effect, but enhancing subsequent satiety due to its potential role as a predictor of protein content. In this study, participants were given different preloads containing varying amounts of MSG and either low-energy carbs or proteins. Those who received the protein-rich preloads showed better energy compensation and reduced their intake at the test meal. Additionally, those who received the MSG plus protein preloads had greater accuracy in energy compensation than those who received the MSG plus carb preloads. These results suggest that MSG may enhance energy compensation when combined with protein-rich foods. This article was authored by Unimacic and Martina Jomans.