 In my opinion, the three most important legacies are one it established for the first time the power of big science in biology and its ability to transform the future of biology. And I was in this regard particularly impressed with the tells estimate of $800 billion benefits, and this is 10 years ago is still coming from the human genome project, in addition to transforming virtually every field of science biological sciences. I think number two, I was impressed with how we gained the access to the human genome to look at genes, but to look at variation and to correlate it with phenotype. And number three, I was most impressed with the fact that the human genome is one of the keys to transforming 21st century medicine by bringing it to a level of understanding each individual that profoundly is going to alter how we practice medicine.